Genetic variation is an important factor for the variation in psychiatric drug response. The meta-analysis conducted by Kirchheiner et al. showed that of 36 commonly used antidepressants, for 20 of those, data on polymorphic CYP2D6 or CYP2C19 were found and that in 14 drugs such genetic variation would require at least doubling of the dose in extensive metabolizers in comparison to poor metabolizers. They also showed that out of 38 antipsychotics, CYP2D6 and CYP2C19 genotype was of relevant in 13 drugs. Amitriptyline has relatively narrow therapeutic range and high toxicity at increased concentrations, leading to severe adverse effects. The main CYPs involved in amitriptyline metabolism are CYP2C19. Genetic variation of these enzymes has been shown to correlate with the serum concentrations of amitriptyline, as well as with the occurrence of side-effects related to amitriptyline therapy.
Sunday, 10 February 2019
Expected inter-patient variability with respect to neurodisorder drug response
Genetic variation is an important factor for the variation in psychiatric drug response. The meta-analysis conducted by Kirchheiner et al. showed that of 36 commonly used antidepressants, for 20 of those, data on polymorphic CYP2D6 or CYP2C19 were found and that in 14 drugs such genetic variation would require at least doubling of the dose in extensive metabolizers in comparison to poor metabolizers. They also showed that out of 38 antipsychotics, CYP2D6 and CYP2C19 genotype was of relevant in 13 drugs. Amitriptyline has relatively narrow therapeutic range and high toxicity at increased concentrations, leading to severe adverse effects. The main CYPs involved in amitriptyline metabolism are CYP2C19. Genetic variation of these enzymes has been shown to correlate with the serum concentrations of amitriptyline, as well as with the occurrence of side-effects related to amitriptyline therapy.
Subscribe to:
Post Comments (Atom)
My husband was diagnosed with early onset Parkinson's disease at 57.his symptoms were shuffling of feet,slurred speech, low volume speech, degradation of hand writing, horrible driving skills, right arm held at 45 degree angle, things were tough for me, but now he finally free from the disease with the help of total cure ultimate health home, he now walks properly and all symptoms has reversed, he had trouble with balance especially at night, getting into the shower and exiting it is difficult,getting into bed is also another thing he finds impossible.we had to find a better solution for his condition which has really helped him a lot,the biggest helped we had was ultimatehealthhome they walked us through the proper steps,am highly recommended this ultimatehealthhome@gmail.com to anyone who needs help.
ReplyDelete